Metabolic syndrome and adiposity: Risk factors for decreased myelin in cognitively healthy adults.

ABSTRACT: Metabolic syndrome (MetS) is a cluster of conditions that affects ∼25% of the global population, including excess adiposity, hyperglycemia, dyslipidemia, and elevated blood pressure. MetS is one of major risk factors not only for chronic diseases, but also for dementia and cognitive dysfunction, although the underlying mechanisms remain poorly understood. White matter is of particular interest in the context of MetS due to the metabolic vulnerability of myelin maintenance, and the accumulating evidence for the importance of the white matter in the pathophysiology of dementia. Therefore, we investigated the associations of MetS risk score and adiposity (combined body mass index and waist circumference) with myelin water fraction measured with myelin water imaging. In 90 cognitively and neur

SUBMITTER: Burzynska AZ 

PROVIDER: S-EPMC10757180 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature