Advanced maternal age has negative multigenerational impacts during Drosophila melanogaster embryogenesis.

ABSTRACT: Increasing maternal age is commonly accompanied by decreased fitness in offspring. In Drosophila melanogaster, maternal senescence negatively affects multiple facets of offspring phenotype and fitness. These maternal effects are particularly large on embryonic viability. Identifying which embryonic stages are disrupted can indicate mechanisms of maternal effect senescence. Some maternal effects can also carry-over to subsequent generations. We examined potential multi- and transgenerational effects maternal senescence on embryonic development in two laboratory strains of D. melanogaster. We categorized the developmental stages of embryos from every combination of old and young mother, grandmother and great grandmother. We then modelled embryonic survival across the stages and

SUBMITTER: Ostberg H 

PROVIDER: S-EPMC10757284 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature