Causal effects of gut microbiota on appendicitis: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Previous research has posited a potential correlation between the gut microbiota and the onset of appendicitis; however, the precise causal connection between appendicitis and the gut microbiota remains an unresolved and contentious issue.

Methods

In this investigation, we performed a Mendelian randomization (MR) analysis employing publicly accessible summary data extracted from genome-wide association studies (GWAS) to elucidate the potential causal nexus between the gut microbiota and the development of appendicitis. We initially identified instrumental variables (IVs) through a comprehensive array of screening methodologies, subsequently executing MR analyses using the Inverse Variance Weighted (IVW) technique as our primary approach, supplemented by several al

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10757326 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature