Periconceptional Serum Creatinine and Risk of Childhood Autism Spectrum Disorder: A Research Letter.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is a neurodevelopmental condition that manifests in early childhood, in which the maternal metabolic syndrome may be a risk factor. The kidney is a barometer of maternal metabolic syndrome duration and severity.

Objective

The main objective of this study is to determine whether periconceptional kidney function is associated with ASD in early childhood.

Design setting and participants

This retrospective population-based cohort study was completed in Ontario, Canada. Included were singleton children born in an Ontario hospital between April 2007 and March 2021, who were alive at age 48 months and whose mother had a recorded prepregnancy body mass index (BMI) and a measured serum creatinine (SCr) between 120 days preconception an

SUBMITTER: Harel Z 

PROVIDER: S-EPMC10757427 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature