Genetic and Nongenetic Components of Stroke Family History: A Population Study of Adopted and Nonadopted Individuals.

ABSTRACT: Background Genetic and nongenetic factors account for the association of family history with disease risk. Comparing adopted and nonadopted individuals provides an opportunity to disentangle those factors. Methods and Results We examined associations between family history of stroke and heart disease with incident stroke and myocardial infarction (MI) in 495 640 UK Biobank participants (mean age, 56.5 years; 55% women) stratified by childhood adoption status (5747 adoptees). We estimated hazard ratios (HRs) per affected family member, and for polygenic risk scores in Cox models adjusted for baseline age and sex. A total of 12 518 strokes and 23 923 MIs occurred over a 13-year follow-up. In nonadoptees, family history of stroke and heart disease was associated with increased stroke and MI r

SUBMITTER: Mayerhofer E 

PROVIDER: S-EPMC10757525 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature