Deletion of adipocyte NOS3 potentiates high-fat diet-induced hypertension and vascular remodelling via chemerin.

ABSTRACT:

Aims

Obesity is an epidemic that is a critical contributor to hypertension and other cardiovascular diseases. Current paradigms suggest that endothelial nitric oxide synthase (eNOS/NOS3) in the vessel wall is the primary regulator of vascular function and blood pressure. However, recent studies have revealed the presence of eNOS/NOS3 in the adipocytes of white adipose tissues and perivascular adipose tissues (PVATs). The current understanding of the role of adipocyte NOS3 is based mainly on studies using global knockout models. The present study aimed to elucidate the functional significance of adipocyte NOS3 for vascular function and blood pressure control.

Methods and results

We generated an adipocyte-specific NOS3 knockout mouse line using adiponectin promoter-specific Cr

SUBMITTER: Man AWC 

PROVIDER: S-EPMC10757584 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature