Predicting the efficacy of glucocorticoids in pediatric primary immune thrombocytopenia using plasma proteomics.

ABSTRACT:

Objective

Primary immune thrombocytopenia (ITP) is the most common acquired autoimmune bleeding disorder among children. While glucocorticoids are the primary first-line treatment for ITP treatment, they prove ineffective in certain patients. The challenge of identifying biomarkers capable of early prediction regarding the response to glucocorticoid therapy in ITP persists. This study aimed to identify ideal biomarkers for predicting glucocorticoid efficacy in patients with ITP using plasma proteomics.

Methods

A four-dimensional data-independent acquisition approach was performed to determine the differentially expressed proteins in plasma samples collected from glucocorticoid-sensitive (GCS) (n=18) and glucocorticoid-resistant (GCR) (n=17) children with ITP treated with pre

SUBMITTER: Cao Q 

PROVIDER: S-EPMC10757608 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature