Tau PET burden in Brodmann areas 35 and 36 is associated with individual differences in cognition in non-demented older adults.

ABSTRACT:

Introduction

The accumulation of neurofibrillary tau tangles, a neuropathological hallmark of Alzheimer's disease (AD), occurs in medial temporal lobe (MTL) regions early in the disease process, with some of the earliest deposits localized to subregions of the entorhinal cortex. Although functional specialization of entorhinal cortex subregions has been reported, few studies have considered functional associations with localized tau accumulation.

Methods

In this study, stepwise linear regressions were used to examine the contributions of regional tau burden in specific MTL subregions, as measured by ¹⁸F-MK6240 PET, to individual variability in cognition. Dependent measures of interest included the Clinical Dementia Rating Sum of Boxes (CDR-SB), Mini Mental State E

SUBMITTER: Rani N 

PROVIDER: S-EPMC10757623 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature