Repetitive spreading depolarization induces gene expression changes related to synaptic plasticity and neuroprotective pathways.

ABSTRACT: Spreading depolarization (SD) is a slowly propagating wave of profound depolarization that sweeps through cortical tissue. While much emphasis has been placed on the damaging consequences of SD, there is uncertainty surrounding the potential activation of beneficial pathways such as cell survival and plasticity. The present study used unbiased assessments of gene expression to evaluate that compensatory and repair mechanisms could be recruited following SD, regardless of the induction method, which prior to this work had not been assessed. We also tested assumptions of appropriate controls and the spatial extent of expression changes that are important for in vivo SD models. SD clusters were induced with either KCl focal application or optogenetic stimulation in healthy mice. Cortic

SUBMITTER: Dell'Orco M 

PROVIDER: S-EPMC10757627 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature