RIPK1 plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibiting both RIPK3- and FADD-mediated cell death.

ABSTRACT: Regulatory T (T_reg) cells play an essential role in maintaining immune balance across various physiological and pathological conditions. However, the mechanisms underlying T_reg homeostasis remain incompletely understood. Here, we report that RIPK1 is crucial for T_reg cell survival and homeostasis. We generated mice with T_reg cell-specific ablation of Ripk1 and found that these mice developed fatal systemic autoimmunity due to a dramatic reduction in the T_reg cell compartment caused by excessive cell death. Unlike conventional T cells, T_reg cells with Ripk1 deficiency were only partially rescued from cell death by blocking FADD-dependent apoptosis. However, simultaneous removal of both Fadd and Ripk3 completely restored the h

SUBMITTER: Deng X 

PROVIDER: S-EPMC10757712 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature