Identification of efferocytosis-related subtypes in gliomas and elucidating their characteristics and clinical significance.

ABSTRACT: Introduction: Gliomas, the most prevalent tumors of the central nervous system, are known for their aggressive nature and poor prognosis. The heterogeneity among gliomas leads to varying responses to the same treatments, even among similar glioma types. In our study, we efferocytosis-related subtypes and explored their characteristics in terms of immune landscape, intercellular communication, and metabolic processes, ultimately elucidating their potential clinical implications. Methods and Results: We first identified efferocytosis-related subtypes in Bulk RNA-seq using the NMF algorithm. We then preliminarily demonstrated the correlation of these subtypes with efferocytosis by examining enrichment scores of cell death pathways, macrophage infiltration, and the expression of

SUBMITTER: Gao M 

PROVIDER: S-EPMC10757721 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature