Evaluating the interplay between estrous cyclicity and flurothyl-induced seizure susceptibility in Scn2a K1422E mice.
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ABSTRACT:
SUBMITTER: Echevarria-Cooper DM
PROVIDER: S-EPMC10757737 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
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Evaluating the interplay between estrous cyclicity and flurothyl-induced seizure susceptibility in <i>Scn2a <sup>K1422E</sup></i> mice.
Echevarria-Cooper Dennis M DM Kearney Jennifer A JA
microPublication biology 20231216
Recently, we demonstrated that <i>Scn2a <sup>K1422E</sup></i> female mice showed a distinct distribution of flurothyl-induced seizure thresholds. To evaluate whether the estrous cycle contributes to this effect, estrous cycle monitoring was performed in mice that had undergone ovariectomy, sham surgery, or no treatment prior to seizure induction. Ovariectomy did not affect the non-unimodal distribution of flurothyl seizure thresholds observed in <i>Scn2a <sup>K1422E</sup></i> females. Additional ...[more]
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