Vaccine induced memory CD8⁺ T cells efficiently prevent viral transmission from the respiratory tract.

ABSTRACT:

Introduction

Mucosal immunization eliciting local T-cell memory has been suggested for improved protection against respiratory infections caused by viral variants evading pre-existing antibodies. However, it remains unclear whether T-cell targeted vaccines suffice for prevention of viral transmission and to which extent local immunity is important in this context.

Methods

To study the impact of T-cell vaccination on the course of viral respiratory infection and in particular the capacity to inhibit viral transmission, we used a mouse model involving natural murine parainfluenza infection with a luciferase encoding virus and an adenovirus based nucleoprotein targeting vaccine.

Results and discussion

Prior intranasal immunization inducing strong mucosal CD8+ T cell immu

SUBMITTER: Zhou J 

PROVIDER: S-EPMC10757911 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature