Profiles of biliary microbiota in biliary obstruction patients with Clonorchis sinensis infection.

ABSTRACT:

Background

Clonorchis sinensis (C. sinensis) is a epidemiologically significant food-borne parasite, causing several hepatobiliary diseases. Biliary microbiota community structure might be influenced by infection with pathogens. However, the biliary microbiome of biliary obstruction patients infected with C. sinensis is still an unexplored aspect.

Methods

A total of 50 biliary obstruction patients were enrolled, including 24 infected with C. sinensis and 26 non-infected subjects. The bile samples were collected by Endoscopic Retrograde Cholangiopancretography. Biliary microbiota alteration was analyzed through high-throughput 16S ribosomal RNA (rRNA) gene sequencing.

Results

Our findings revealed that there was significant increase in both

SUBMITTER: Chen R 

PROVIDER: S-EPMC10757933 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature