Impact of statin use on breast cancer recurrence and mortality before and after diagnosis: a systematic review and meta-analysis.

ABSTRACT:

Objective

Breast cancer is one of the most common causes of death among women. Statins, typically used for cholesterol management, have been hypothesized to reduce recurrence and mortality rates in breast cancer. However, this association remains a subject of debate. This study evaluates the potential impact of statins on breast cancer recurrence and mortality.

Methods

A comprehensive search was conducted in the PubMed, EMBASE, and Cochrane databases for articles published up to June 2023. These articles examined the effect of statins on breast cancer recurrence and mortality both before and after diagnosis. The analysis was performed using random-effects models, calculating pooled hazard ratios (HR) and their 95% confidence intervals (CI).

Results

A total of 31 cohor

SUBMITTER: Jia X 

PROVIDER: S-EPMC10757972 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature