Inactivation of the NLRP3 inflammasome mediates exosome-based prevention of atrial fibrillation.

ABSTRACT: Rationale: Extracellular vesicles (EVs) from human explant-derived cells injected directly into the atria wall muscle at the time of open chest surgery reduce atrial fibrosis, atrial inflammation, and atrial fibrillation (AF) in a rat model of sterile pericarditis. Albeit a promising solution to prevent postoperative AF, the mechanism(s) underlying this effect are unknown and it is not clear if this benefit is dependent on EV dose. Methods: To determine the dose-efficacy relationship of EVs from human explant-derived cells in a rat model of sterile pericarditis. Increasing doses of EVs (10⁶, 10⁷, 10⁸ or 10⁹) or vehicle control were injected into the atria of middle-age male Sprague-Dawley rats at the time of talc application. A sham

SUBMITTER: Parent S 

PROVIDER: S-EPMC10758048 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature