Ontology highlight
ABSTRACT:
SUBMITTER: Tian S
PROVIDER: S-EPMC10758103 | biostudies-literature | 2024
REPOSITORIES: biostudies-literature
Tian Shaoping S Wang Rui R Wang Yiting Y Chen Ruibing R Lin Tianyu T Xiao Xuesong X Liu Xinyu X Ideozu Justin Eze JE Geng Hua H Wang Yong Y Yue Dan D
International journal of biological sciences 20240101 2
A key player in mitochondrial respiration, p32, often referred to as C1QBP, is mostly found in the mitochondrial matrix. Previously, we showed that p32 interacts with DLAT in the mitochondria. Here, we found that p32 expression was reduced in ccRCC and suppressed progression and metastasis in ccRCC animal models. We observed that increasing p32 expression led to an increase in oxidative phosphorylation by interacting with DLAT, thus, regulating the activation of the pyruvate dehydrogenase comple ...[more]