Plasma metabolomic analysis of human hepatocellular carcinoma before and after transcatheter arterial chemoembolization.

ABSTRACT: Introduction: Hepatocellular carcinoma (HCC) is the fourth most prevalent cancer in China. Transcatheter arterial chemoembolization (TACE) is a common interventional therapy for HCC. In this study, we aimed to explore specific metabolites that can accurately predict prognosis after TACE in patients with HCC. Methods: Patients with HCC and healthy volunteers (n = 20 each) were recruited to our study; plasma samples were collected from patients before and after TACE and from healthy volunteers. Plasma samples were subjected to untargeted ultra-high performance liquid chromatography-high resolution mass spectrometry metabolomics analysis, to identify metabolites significantly associated with the prognosis of patients with HCC after TACE. Results: Orthogonal filtered parti

SUBMITTER: Fan J 

PROVIDER: S-EPMC10758137 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature