Aortic calcification accelerates cardiac dysfunction via inducing apoptosis of cardiomyocytes.

ABSTRACT: Vascular calcification (VC) is a known predictor of cardiovascular events in patients with atherosclerosis and chronic renal disease. However, the exact relationship between VC and cardiovascular mortality remains unclear. Herein, we investigated the underlying mechanisms between VC progression, arterial stiffness, and cardiac dysfunction. C57BL/6 mice were administered intraperitoneally vitamin D₃ (VD₃) at a dosage of 35×10⁴ IU/day for 14 days. At day 42, VC extent, artery elasticity, carotid artery blood flow, aorta pulse propagation velocity, cardiac function, and pathological changes were evaluated. Heart apoptosis was detected using TUNEL and immunohistochemistry staining. In vitro, rat cardiomyocytes H9C2 were exposed to media from calcified ra

SUBMITTER: Hao N 

PROVIDER: S-EPMC10758138 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature