Tissue-specific features of the T cell repertoire after allogeneic hematopoietic cell transplantation in human and mouse.

ABSTRACT: T cells are the central drivers of many inflammatory diseases, but the repertoire of tissue-resident T cells at sites of pathology in human organs remains poorly understood. We examined the site-specificity of T cell receptor (TCR) repertoires across tissues (5 to 18 tissues per patient) in prospectively collected autopsies of patients with and without graft-versus-host disease (GVHD), a potentially lethal tissue-targeting complication of allogeneic hematopoietic cell transplantation, and in mouse models of GVHD. Anatomic similarity between tissues was a key determinant of TCR repertoire composition within patients, independent of disease or transplant status. The T cells recovered from peripheral blood and spleens in patients and mice captured a limited portion of the TCR repertoire detec

SUBMITTER: DeWolf S 

PROVIDER: S-EPMC10758167 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature