Acoustic stimulation during sleep predicts long-lasting increases in memory performance and beneficial amyloid response in older adults.

ABSTRACT:

Background

Sleep and neurodegeneration are assumed to be locked in a bi-directional vicious cycle. Improving sleep could break this cycle and help to prevent neurodegeneration. We tested multi-night phase-locked acoustic stimulation (PLAS) during slow wave sleep (SWS) as a non-invasive method to improve SWS, memory performance and plasma amyloid levels.

Methods

32 healthy older adults (agemean: 68.9) completed a between-subject sham-controlled three-night intervention, preceded by a sham-PLAS baseline night.

Results

PLAS induced increases in sleep-associated spectral-power bands as well as a 24% increase in slow wave-coupled spindles, known to support memory consolidation. There was no significant group-difference in memory performance or amyloid-beta between the inte

SUBMITTER: Wunderlin M 

PROVIDER: S-EPMC10758173 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature