Safety and Efficacy of Subcutaneous Daratumumab in Systemic AL Amyloidosis.

ABSTRACT:

Introduction

Systemic AL amyloidosis, a plasma cell dyscrasia, is characterized by the production of misfolded immunoglobulin light chain. These misfolded proteins aggregate into amyloid fibrils and deposit throughout the body, resulting in widespread organ dysfunction and ultimately death. Achieving rapid and maximal elimination of the plasma cell clone is crucial to long-term survival. Daratumumab, an anti-CD38 monoclonal antibody delivered intravenously, has been swiftly incorporated into standard first-line treatment regimens. A novel formulation of daratumumab has been developed that can be injected subcutaneously.

Areas covered

As a retrospective qualitative review of prior publications involving daratumumab, this work briefly summarizes the existing data regarding the

SUBMITTER: Hughes MS 

PROVIDER: S-EPMC10758190 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature