SP7: from Bone Development to Skeletal Disease.

ABSTRACT:

Purpose of review

The purpose of this review is to summarize the different roles of the transcription factor SP7 in regulating bone formation and remodeling, discuss current studies in investigating the causal relationship between SP7 mutations and human skeletal disease, and highlight potential therapeutic treatments that targeting SP7 and the gene networks that it controls.

Recent findings

Cell-type and stage-specific functions of SP7 have been identified during bone formation and remodeling. Normal bone development regulated by SP7 is strongly associated with human bone health. Dysfunction of SP7 results in common or rare skeletal diseases, including osteoporosis and osteogenesis imperfecta with different inheritance patterns. SP7-associated signaling pathways, SP7-depend

SUBMITTER: Wang JS 

PROVIDER: S-EPMC10758296 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature