Positive Association of TEAD1 With Schizophrenia in a Northeast Chinese Han Population.

ABSTRACT:

Objective

Schizophrenia is a complex and devastating psychiatric disorder with a strong genetic background. However, much uncertainty still exists about the role of genetic susceptibility in the pathophysiology of schizophrenia. TEA domain transcription factor 1 (TEAD1) is a transcription factor associated with neurodevelopment and has modulating effects on various nervous system diseases. In the current study, we performed a case-control association study in a Northeast Chinese Han population to explore the characteristics of pathogenic TEAD1 polymorphisms and potential association with schizophrenia.

Methods

We recruited a total of 721 schizophrenia patients and 1,195 healthy controls in this study. The 9 single nucleotide polymorphisms (SNPs) in the gene region of TEAD1 w

SUBMITTER: Sun Y 

PROVIDER: S-EPMC10758319 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature