Comparative Safety of Long-Acting Injectable Antipsychotics: A Systematic Review and Network Meta-Analysis.

ABSTRACT:

Objective

To find the safety of long-acting injectable antipsychotics (LAIs) compared to each other, and/or placebo in the treatment of schizophrenia (SCZ) and/or schizoaffective disorder (SZA).

Methods

We performed a systematic review and a network meta-analysis of randomized controlled trials (RCTs) comparing the safety of LAIs versus other LAIs or placebo in adults diagnosed with SCZ or SZA. The primary outcomes were treatment emergent adverse events (TEAEs), serious treatment emergent adverse events (STEAEs), and deaths. The secondary outcomes included treatment discontinuations due to adverse events and all-cause discontinuations.

Results

Seventeen RCTs were included (n=7,908). There were no significant differences between LAIs and placebo in the risk of presenti

SUBMITTER: Uribe ES 

PROVIDER: S-EPMC10758324 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature