Gut microbiota landscape and potential biomarker identification in female patients with systemic lupus erythematosus using machine learning.

ABSTRACT:

Objectives

Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease that disproportionately affects women. Early diagnosis and prevention are crucial for women's health, and the gut microbiota has been found to be strongly associated with SLE. This study aimed to identify potential biomarkers for SLE by characterizing the gut microbiota landscape using feature selection and exploring the use of machine learning (ML) algorithms with significantly dysregulated microbiotas (SDMs) for early identification of SLE patients. Additionally, we used the SHapley Additive exPlanations (SHAP) interpretability framework to visualize the impact of SDMs on the risk of developing SLE in females.

Methods

Stool samples were collected from 54 SLE patients and 55 Negative Controls (NC)

SUBMITTER: Song W 

PROVIDER: S-EPMC10758415 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature