Causal functional connectivity in Alzheimer's disease computed from time series fMRI data.

ABSTRACT: Functional connectivity between brain regions is known to be altered in Alzheimer's disease and promises to be a biomarker for early diagnosis. Several approaches for functional connectivity obtain an un-directed network representing stochastic associations (correlations) between brain regions. However, association does not necessarily imply causation. In contrast, Causal Functional Connectivity (CFC) is more informative, providing a directed network representing causal relationships between brain regions. In this paper, we obtained the causal functional connectome for the whole brain from resting-state functional magnetic resonance imaging (rs-fMRI) recordings of subjects from three clinical groups: cognitively normal, mild cognitive impairment, and Alzheimer's disease. We applied

SUBMITTER: Biswas R 

PROVIDER: S-EPMC10758424 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature