Mendelian randomization indicates causal effects of estradiol levels on kidney function in males.

ABSTRACT:

Context

Chronic kidney disease (CKD) is a public health burden worldwide. Epidemiological studies observed an association between sex hormones, including estradiol, and kidney function.

Objective

We conducted a Mendelian randomization (MR) study to assess a possible causal effect of estradiol levels on kidney function in males and females.

Design

We performed a bidirectional two-sample MR using published genetic associations of serum levels of estradiol in men (n = 206,927) and women (n = 229,966), and of kidney traits represented by estimated glomerular filtration rate (eGFR, n = 567,460), urine albumin-to-creatinine ratio (UACR, n = 547,361), and CKD (n = 41,395 cases and n = 439,303 controls) using data obtained from the CK

SUBMITTER: Nasr MK 

PROVIDER: S-EPMC10758447 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature