Synergistic potential of teriflunomide with fluconazole against resistant Candida albicans in vitro and in vivo.

ABSTRACT:

Introduction

Candida albicans is the primary cause of systemic candidiasis, which is involved in high morbidity and mortality. Drug resistance exacerbates these problems. In addition, there are limited antifungal drugs available. In order to solve these problems, combination therapy has aroused great interest. Teriflunomide is an immunosuppressant. In the present work, we aimed to identify whether teriflunomide can reverse the resistance of Candida albicans in the presence of sub-inhibitory concentrations of fluconazole in vitro and in vivo.

Methods

Seven Candida albicans isolates were used in this study. Susceptibility of Candida albicans in vitro to the drugs was determined using a checkerboard microdilution assay in accordance wit

SUBMITTER: Li X 

PROVIDER: S-EPMC10758495 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature