Biomaterial-assisted local oxygenation safeguards the prostimulatory phenotype and functions of human dendritic cells in hypoxia.

ABSTRACT: Dendritic cells (DCs), professional antigen-presenting cells, function as sentinels of the immune system. DCs initiate and fine-tune adaptive immune responses by presenting antigenic peptides to B and T lymphocytes to mount an effective immune response against cancer and pathogens. However, hypoxia, a condition characterized by low oxygen (O₂) tension in different tissues, significantly impacts DC functions, including antigen uptake, activation and maturation, migration, as well as T-cell priming and proliferation. In this study, we employed O₂-releasing biomaterials (O₂-cryogels) to study the effect of localized O₂ supply on human DC phenotype and functions. Our results indicate that O₂-cryogels effectively mitigate DC exposure to hyp

SUBMITTER: Bhatt K 

PROVIDER: S-EPMC10758617 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature