A retrospective analysis of ibrutinib outcomes in relapsed or refractory mantle cell lymphoma.

ABSTRACT:

Background

While treatment strategies for mantle cell lymphoma (MCL) have evolved, patients often experience disease progression and require additional treatment therapies. Ibrutinib presents a promising option for relapsed or refractory MCL (RR-MCL). This study investigated real-world treatment outcomes of ibrutinib in patients with RR-MCL.

Methods

A single-center retrospective analysis investigated clinical characteristics and survival outcomes of patients with RR-MCL, treated with ibrutinib.

Results

Forty-two patients were included, with 16 received rituximab and bendamustine, and 26 receiving anthracycline-based regimens as front-line treatment. During a median follow-up of 46.0 months, the response rate to ibrutinib was 69%, with 12 CRs and 8 partial responses. D

SUBMITTER: Lee YP 

PROVIDER: S-EPMC10758639 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature