Dataset Information

Association of MBOAT7 rs641738 polymorphism with hepatocellular carcinoma susceptibility: A systematic review and meta-analysis.

ABSTRACT:

Background

The MBOAT7 rs641738 single-nucleotide polymorphism (SNP) has been proven to influence various liver diseases, but its association with hepatocellular carcinoma (HCC) susceptibility has been debated. To address this discrepancy, we conducted the current systematic review and meta-analysis.

Aim

To perform a systematic review and meta-analysis on association of MBOAT7 SNP and HCC susceptibility.

Methods

We performed a systematic review in PubMed, Web of Science, Scopus, and EMBASE; applied specific inclusion and exclusion criteria; and extracted the data. Meta-analysis was conducted with the meta package in R. Sensitivity and subgroup analyses were also performed. This meta-analysis was registered in PROSPERO (CRD42023458046).

Results

Eight studies were included in the systematic review, and 12 cohorts from 6 studies were included in the meta-analysis. Our meta-analysis revealed an association between the MBOAT7 SNP and HCC susceptibility in both the dominant [odds ratio (OR): 1.14, 95% confidence interval (95%CI): 1.02-1.26, P = 0.020] and recessive (OR: 1.21, 95%CI: 1.05-1.39, P = 0.008) models. Subgroup analysis revealed that stratification of the included patients by geographical origin showed a significant association in Asia (OR: 1.20, 95%CI: 1.03-1.39).

Conclusion

This meta-analysis underscores the contribution of the MBOAT7 rs641738 SNP to hepatocarcinogenesis, especially in Asian populations, which warrants further investigation.

SUBMITTER: Lai M

PROVIDER: S-EPMC10758655 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Publications

Association of <i>MBOAT7</i> rs641738 polymorphism with hepatocellular carcinoma susceptibility: A systematic review and meta-analysis.

Lai Min M Qin Ya-Lu YL Jin Qiong-Yu QY Chen Wen-Jing WJ Hu Jia J

World journal of gastrointestinal oncology 20231201 12

<h4>Background</h4>The <i>MBOAT7</i> rs641738 single-nucleotide polymorphism (SNP) has been proven to influence various liver diseases, but its association with hepatocellular carcinoma (HCC) susceptibility has been debated. To address this discrepancy, we conducted the current systematic review and meta-analysis.<h4>Aim</h4>To perform a systematic review and meta-analysis on association of <i>MBOAT7</i> SNP and HCC susceptibility.<h4>Methods</h4>We performed a systematic review in PubMed, Web o ...[more]

PMID: 38173430

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