Small vessel disease burden and functional brain connectivity in mild cognitive impairment.

ABSTRACT:

Background

The role of small vessel disease in the development of dementia is not yet completely understood. Functional brain connectivity has been shown to differ between individuals with and without cerebral small vessel disease. However, a comprehensive measure of small vessel disease quantifying the overall damage on the brain is not consistently used and studies using such measure in mild cognitive impairment individuals are missing.

Method

Functional brain connectivity differences were analyzed between mild cognitive impairment individuals with absent or low (n = 34) and high (n = 34) small vessel disease burden using data from the Parelsnoer Institute, a Dutch multicenter study. Small vessel disease was characterized using an ordinal scale considering: l

SUBMITTER: Marcolini S 

PROVIDER: S-EPMC10758699 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature