Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates.

ABSTRACT:

Background

Increasing evidence supports that antibodies can protect against active tuberculosis (TB) but knowledge of potentially protective antigens, especially in the airways, is limited. The main objective of this study was to identify antigen-specific airway and systemic immunoglobulin isotype responses associated with the outcome of controlled latent Mycobacterium tuberculosis (Mtb) infection (LTBI) versus uncontrolled infection (TB) in nonhuman primates.

Methods

In a case-control design, using non-parametric group comparisons with false discovery rate adjustments, we assessed antibodies in 57 cynomolgus macaques which, following low-dose airway Mtb infection, developed either LTBI or TB. We investigated airway and systemic IgG, IgA, and IgM responses in paired bronchoa

SUBMITTER: Ishida E 

PROVIDER: S-EPMC10758715 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature