Lung cancer progression alters lung and gut microbiomes and lipid metabolism.

ABSTRACT: Despite advances in medical technology, lung cancer still has one of the highest mortality rates among all malignancies. Therefore, efforts must be made to understand the precise mechanisms underlying lung cancer development. In this study, we conducted lung and gut microbiome analyses and a comprehensive lipid metabolome analysis of host tissues to assess their correlation. Alternations in the lung microbiome due to lung cancer, such as a significantly decreased abundance of Firmicutes and Deferribacterota, were observed compared to a mock group. However, mice with lung cancer had significantly lower relative abundances of Actinobacteria and Proteobacteria and higher relative abundances of Cyanobacteria and Patescibacteria in the gut microbiome. T

SUBMITTER: Hagihara M 

PROVIDER: S-EPMC10758782 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature