Cardiac Amyloid Quantification Using ¹²⁴I-Evuzamitide (¹²⁴I-P5+14) Versus ¹⁸F-Florbetapir: A Pilot PET/CT Study.

ABSTRACT:

Background

Cardiac amyloid quantification could advance early diagnosis of amyloid cardiomyopathy (CMP) and treatment monitoring. However, current imaging tools are based on indirect measurements. ¹²⁴I-evuzamitide is a novel pan-amyloid radiotracer binding to amyloid deposits from multiple amyloidogenic proteins. Its ability to quantify cardiac amyloid has not yet been investigated.

Objectives

The objectives of this pilot study were to quantify myocardial ¹²⁴I-evuzamitide uptake and to compare its diagnostic value to ¹⁸F-florbetapir in participants with amyloid CMP and control subjects.

Methods

This study included 46 participants: 12 with light-chain (AL) CMP, 12 with wild-type transthyretin (ATTRwt) CMP, 2 with hereditary amyloidosis,

SUBMITTER: Clerc OF 

PROVIDER: S-EPMC10758980 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature