Restoring periodontal tissue homoeostasis prevents cognitive decline by reducing the number of Serpina3n^high astrocytes in the hippocampus.

ABSTRACT: Cognitive decline has been linked to periodontitis through an undetermined pathophysiological mechanism. This study aimed to explore the mechanism underlying periodontitis-related cognitive decline and identify therapeutic strategies for this condition. Using single-nucleus RNA sequencing we found that changes in astrocyte number, gene expression, and cell‒cell communication were associated with cognitive decline in mice with periodontitis. In addition, activation of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome was observed to decrease the phagocytic capability of macrophages and reprogram macrophages to a more proinflammatory state in the gingiva, thus aggravating periodontitis. To further investigate this finding, lipid-based nanoparticles carrying NLRP3 si

SUBMITTER: Shen Z 

PROVIDER: S-EPMC10758991 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature