Timing of Phagosome Maturation Depends on Their Transport Switching from Actin to Microtubule Tracks.

ABSTRACT: Phagosomes, specialized membrane compartments responsible for digesting internalized pathogens, undergo sequential dynamic and biochemical changes as they mature from nascent phagosomes to degradative phagolysosomes. Maturation of phagosomes depends on their transport along actin filaments and microtubules. However, the specific quantitative relationship between the biochemical transformation and transport dynamics remains poorly characterized. The autonomous nature of phagosomes, moving and maturing at different rates, makes understanding this relationship challenging. Addressing this challenge, in this study we engineered particle sensors to image and quantify single phagosomes' maturation. We found that as phagosomes move from the actin cortex to microtubule tracks, the timing of their

SUBMITTER: Yu Y 

PROVIDER: S-EPMC10759163 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature