Nanoscale coordination polymer Fe-DMY downregulating Poldip2-Nox4-H₂O₂ pathway and alleviating diabetic retinopathy.

ABSTRACT: Diabetic retinopathy (DR) is a prevalent microvascular complication of diabetes and the leading cause of blindness and severe visual impairment in adults. The high levels of glucose trigger multiple intracellular oxidative stress pathways, such as POLDIP2, resulting in excessive reactive oxygen species (ROS) production and increased expression of vascular cell adhesion molecule-1 (VCAM-1), hypoxia-inducible factor 1α (HIF-1α), and vascular endothelial growth factor (VEGF), causing microvascular dysfunction. Dihydromyricetin (DMY) is a natural flavonoid small molecule antioxidant. However, it exhibits poor solubility in physiological environments, has a short half-life in vivo, and has low oral bioavailability. In this study, we present, for the first time, the synthesis of ultra-small Fe-D

SUBMITTER: Gui SY 

PROVIDER: S-EPMC10759264 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature