Expression of NELL2/NICOL-ROS1 lumicrine signaling-related molecules in the human male reproductive tract.

ABSTRACT: The maturation of spermatozoa is a regulated process, influenced by genes expressing essential secreted proteins in the proximal epididymis. Recent genetic studies in rodents have identified the non-sex steroidal molecular signals that regulate gene expression in the proximal epididymis. Germ cells in the testis secrete ligand proteins into the seminiferous tubule lumen The ligand proteins travel through the male reproductive tract lumen to the epididymis, where they bind to receptors, triggering the differentiation of the luminal epithelium for sperm maturation. It is, however, not fully unveiled if such a testis-epididymis trans-luminal signaling mechanism exists in other species, especially humans. In the present study, the rodent-type testis-epididymis trans-luminal signaling in the hu

SUBMITTER: Kiyozumi D 

PROVIDER: S-EPMC10759339 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature