Association of chronic hepatitis B infection with hepatic steatosis and injury in nonalcoholic fatty liver disease children.

ABSTRACT:

Background

The influence of chronic hepatitis B infection (CBI) on hepatic steatosis, necroinflammation, and fibrosis in nonalcoholic fatty liver disease (NAFLD) population was unclear. We aimed to investigate the effect of CBI on hepatic steatosis and assess the association between NAFLD co-existed CBI and hepatic injury in NAFLD pediatric population.

Methods

Consecutive hospitalized children with biopsy-proven NAFLD with or without CBI were included. Hepatic steatosis, necroinflammation and fibrosis were evaluated by NASH CRN system and/or METAVIR scoring system, appropriately. Using multivariate logistic analysis, we identified variables associated with hepatic steatosis and liver injury.

Results

Of 223 biopsy-proven NAFLD children, 161 were NAFLD without CBI, and

SUBMITTER: Wang L 

PROVIDER: S-EPMC10759402 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature