Degraded inferior colliculus responses to complex sounds in prenatally exposed VPA rats.

ABSTRACT:

Background

Individuals with autism spectrum disorders (ASD) often exhibit altered sensory processing and deficits in language development. Prenatal exposure to valproic acid (VPA) increases the risk for ASD and impairs both receptive and expressive language. Like individuals with ASD, rodents prenatally exposed to VPA exhibit degraded auditory cortical processing and abnormal neural activity to sounds. Disrupted neuronal morphology has been documented in earlier processing areas of the auditory pathway in VPA-exposed rodents, but there are no studies documenting early auditory pathway physiology. Therefore, the objective of this study is to characterize inferior colliculus (IC) responses to different sounds in rats prenatally exposed to VPA compared to saline-exposed rats.

Metho

SUBMITTER: Tamaoki Y 

PROVIDER: S-EPMC10759431 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature