Functional annotation of a divergent genome using sequence and structure-based similarity.

ABSTRACT:

Background

Microsporidia are a large taxon of intracellular pathogens characterized by extraordinarily streamlined genomes with unusually high sequence divergence and many species-specific adaptations. These unique factors pose challenges for traditional genome annotation methods based on sequence similarity. As a result, many of the microsporidian genomes sequenced to date contain numerous genes of unknown function. Recent innovations in rapid and accurate structure prediction and comparison, together with the growing amount of data in structural databases, provide new opportunities to assist in the functional annotation of newly sequenced genomes.

Results

In this study, we established a workflow that combines sequence and structure-based functional gene annotation approach

SUBMITTER: Svedberg D 

PROVIDER: S-EPMC10759460 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature