Partial loss of Sorting Nexin 27 resembles age- and Down syndrome-associated T cell dysfunctions.

ABSTRACT:

Background

Sorting Nexin 27 (SNX27)-retromer complex facilitates cargo recycling from endosomes to the plasma membrane. SNX27 downregulation in neurons, as the result of Trisomy 21 (T21), has been linked with cognitive deficits due to impairment of AMPA and NMDA receptor recycling. Studies in human T cell lines likewise demonstrated that SNX27 regulates the correct delivery of cargoes to the immune synapse limiting the activation of pro-inflammatory pathways. Nevertheless, the physiological consequences of partial SNX27 loss in T cell homeostasis are still unclear.

Results

In this study, we have explored the consequences of T cell specific partial SNX27 downregulation in mice. T cells with partial SNX27 deficiency show a marked deficit in the CD4⁺ T cell pool, a h

SUBMITTER: Rodriguez-Rodriguez C 

PROVIDER: S-EPMC10759489 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature