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Ribosomal profiling of human endogenous retroviruses in healthy tissues.

ABSTRACT: Human endogenous retroviruses (HERVs) are the germline embedded proviral fragments of ancient retroviral infections that make up roughly 8% of the human genome. Our understanding of HERVs in physiology primarily surrounds their non-coding functions, while their protein coding capacity remains virtually uncharacterized. Therefore, we applied the bioinformatic pipeline "hervQuant" to high-resolution ribosomal profiling of healthy tissues to provide a comprehensive overview of translationally active HERVs. We find that HERVs account for 0.1-0.4% of all translation in distinct tissue-specific profiles. Collectively, our study further supports claims that HERVs are actively translated throughout healthy tissues to provide sequences of retroviral origin to the human proteome.

SUBMITTER: Dopkins N

PROVIDER: S-EPMC10759522 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Ribosomal profiling of human endogenous retroviruses in healthy tissues.

Dopkins Nicholas N Singh Bhavya B Michael Stephanie S Zhang Panpan P Marston Jez L JL Fei Tongyi T Singh Manvendra M Feschotte Cedric C Collins Nicholas N Bendall Matthew L ML Nixon Douglas F DF

BMC genomics 20240102 1

Human endogenous retroviruses (HERVs) are the germline embedded proviral fragments of ancient retroviral infections that make up roughly 8% of the human genome. Our understanding of HERVs in physiology primarily surrounds their non-coding functions, while their protein coding capacity remains virtually uncharacterized. Therefore, we applied the bioinformatic pipeline "hervQuant" to high-resolution ribosomal profiling of healthy tissues to provide a comprehensive overview of translationally activ ...[more]

PMID: 38166631

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