Association between single nucleotide polymorphisms, TGF-β1 promoter methylation, and polycystic ovary syndrome.

ABSTRACT:

Background

Polycystic ovarian syndrome (PCOS) is a common endocrine and metabolic disease in women. Hyperandrogenaemia (HA) and insulin resistance (IR) are the basic pathophysiological characteristics of PCOS. The aetiology of PCOS has not been fully identified and is generally believed to be related to the combined effects of genetic, metabolic, internal, and external factors. Current studies have not screened for PCOS susceptibility genes in a large population. Here, we aimed to study the effect of TGF-β1 methylation on the clinical PCOS phenotype.

Methods

In this study, three generations of family members with PCOS with IR as the main characteristic were selected as research subjects. Through whole exome sequencing and bioinformatic analysis, TGF-β1 was screened as the PC

SUBMITTER: Gao M 

PROVIDER: S-EPMC10759533 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature