Analyzing lung cancer risks in patients with impaired pulmonary function through characterization of gut microbiome and metabolites.

ABSTRACT:

Background

Lung cancer (LC) is one of the most devastating diseases worldwide, there is growing studies confirm the role of impaired lung function in LC susceptibility. Moreover, gut microbiota dysbiosis is associated with LC severity. Whether alterations in gut microbiota and metabolites are associated with long-term lung dysfunction in LC patients remain unclear. Our study aimed to analyze the risk factors in LC patients with impaired pulmonary function based on the characteristics of the gut microbiome and metabolites.

Methods

Fecal samples from 55 LC patients and 28 benign pulmonary nodules patients were collected. Pulmonary ventilation function was graded according to the American Thoracic Society/ European Respiratory Society (ATS/ERS) method. LC patients were divided

SUBMITTER: Luan J 

PROVIDER: S-EPMC10759599 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature