A preliminary exploration on the mechanism of the carbapenem-resistance transformation of Serratia marcescens in vivo.

ABSTRACT:

Background

The infection of carbapenem-resistant organisms was a huge threat to human health due to their global spread. Dealing with a carbapenem-resistant Serratia marcescens (CRSM) infection poses a significant challenge in clinical settings. This study aims to provide insights into strategies for controlling CRSM infection by exploring the transformation mechanism of carbapenem-resistance.

Methods

We used whole genome sequencing (WGS) to investigate the mechanism of carbapenem resistance in 14 S. marcescens isolates in vivo. The expression level of related genes and the minimum inhibitory concentration of meropenem (MIC_MEM) were also evaluated to confirm the mechanism of carbapenem resistance.

Results

Seven groups of S. marcescens, each consisting of tw

SUBMITTER: Xu Q 

PROVIDER: S-EPMC10759614 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature