An aging-related immune landscape in the hematopoietic immune system.

ABSTRACT:

Background

Aging is a holistic change that has a major impact on the immune system, and immunosenescence contributes to the overall progression of aging. The bone marrow is the most important hematopoietic immune organ, while the spleen, as the most important extramedullary hematopoietic immune organ, maintains homeostasis of the human hematopoietic immune system (HIS) in cooperation with the bone marrow. However, the overall changes in the HIS during aging have not been described. Here, we describe a hematopoietic immune map of the spleen and bone marrow of young and old mice using single-cell sequencing and flow cytometry techniques.

Results

We observed extensive, complex changes in the HIS during aging. Compared with young mice, the immune cells of aged mice showed a mark

SUBMITTER: Lv J 

PROVIDER: S-EPMC10759628 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature