Correlation between TCF7L2 and CAPN10 gene polymorphisms and gestational diabetes mellitus in different geographical regions: a meta-analysis.

ABSTRACT:

Background

The association between TCF7L2 and CAPN10 gene polymorphisms and gestational diabetes mellitus (GDM) has been explored in diverse populations across different geographical regions. Yet, most of these studies have been confined to a limited number of loci, resulting in inconsistent findings. In this study, we conducted a comprehensive review of published literature to identify studies examining the relationship between TCF7L2 and CAPN10 gene polymorphisms and the incidence of GDM in various populations. We specifically focused on five loci that were extensively reported in a large number of publications and performed a meta-analysis.

Methods

We prioritized the selection of SNPs with well-documented correlations established in existing literature on GDM. We searched

SUBMITTER: He J 

PROVIDER: S-EPMC10759658 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature